Article
Circulating tumour-derived KRAS mutations in pancreatic cancer cases are predominantly carried by very short fragments of cell-free DNA.
EBioMedicine - 1 May 2020
Zvereva Maria, Roberti Gabriel, Durand Geoffroy, Voegele Catherine, Nguyen Minh Dao, Delhomme Tiffany M, Chopard Priscilia, Fabianova Eleonora, Adamcakova Zora, Holcatova Ivana, Foretova Lenka, Janout Vladimir, Brennan Paul, Foll Matthieu, Byrnes Graham B, McKay James D, Scelo Ghislaine, Le Calvez-Kelm Florence
Abstract excerpt
BACKGROUND: The DNA released into the bloodstream by malignant tumours· called circulating tumour DNA (ctDNA), is often a small fraction of total cell-free DNA shed predominantly by hematopoietic cells and is therefore challenging to detect. Understanding the biological properties of ctDNA is key to the investigation of its clinical relevance as a non-invasive marker for cancer detection and monitoring. METHODS:...
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