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Detection of mutated KRAS, TP53, CDKN2A, and SMAD4 in tumor cell-free DNA of Brazilian pancreatic adenocarcinoma patients using next-generation sequencing.

Scientific reports - 11 Mar 2026

Marin Anelis Maria, Timoner Branca Engel, Araújo Diogo Dias, Uno Miyuki, Alves Maria José Ferreira, Chammas Roger, Namur Guilherme Naccache, Wosniaki Denise Kusma, Canzian Federico, Blanes Lucas, Zanette Dalila Lucíola, Aoki Mateus Nóbrega

Abstract excerpt

Pancreatic adenocarcinoma (PDAC) is one of the most lethal cancer types worldwide, with early diagnosis being challenging due to nonspecific symptoms that are often noticed only when the tumor reaches a large size. Liquid biopsy has emerged as a promising technology in oncology, where the identification of tumoral cell-free DNA (cfDNA) using sensitive methodologies can identify genetic mutations, allowing for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclin-Dependent Kinase Inhibitor p16

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Source

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Identifiers

PMID: 41813780
DOI: 10.1038/s41598-026-42403-4
PMCID: PMC13100128

Genes

SMAD4
KRAS
TP53
CDKN2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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