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Analysis of cell-free circulating tumor DNA in 419 patients with glioblastoma and other primary brain tumors

11 Mar 2019

Abstract excerpt

Aim: Genomically matched trials in primary brain tumors (PBTs) require recent tumor sequencing. We evaluated whether circulating tumor DNA (ctDNA) could facilitate genomic interrogation in these patients. Methods: Data from 419 PBT patients tested clinically with a ctDNA NGS panel at a CLIA-certified laboratory were analyzed. Results: A total of 211 patients (50%) had ≥1 somatic alteration detected. Detection was...

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PMID: 30855176
DOI: 10.2217/cns-2018-0015

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