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Circulating Tumor DNA in Adults With Glioma: A Systematic Review and Meta-Analysis of Biomarker Performance.

Neurosurgery - 1 Aug 2022

McMahon James Tanner, Studer Matthew, Ulrich Bryan, Revuelta Barbero Juan M, Pradilla Ivan, Palacios-Ariza Maria A, Pradilla Gustavo

Abstract excerpt

BACKGROUND: Circulating tumor DNA (ctDNA) has emerged as a promising noninvasive biomarker to capture tumor genetics in patients with brain tumors. Research into its clinical utility, however, has not been standardized because the sensitivity and specificity of ctDNA remain undefined. OBJECTIVE: To (1) review the primary literature about ctDNA in adults with glioma to compare the sensitivity and specificity of...

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PMID: 35535984
DOI: 10.1227/neu.0000000000001982

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