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Article

Genomic Alterations in Circulating Tumor DNA from Diverse Cancer Patients Identified by Next-Generation Sequencing.

Cancer research - 1 Oct 2017

Schwaederle Maria, Chattopadhyay Ranajoy, Kato Shumei, Fanta Paul T, Banks Kimberly C, Choi In Sil, Piccioni David E, Ikeda Sadakatsu, Talasaz AmirAli, Lanman Richard B, Bazhenova Lyudmila, Kurzrock Razelle

Abstract excerpt

Noninvasive genomic profiling of tumors may be possible with next-generation sequencing (NGS) of blood-derived circulating tumor DNA (ctDNA), but proof of concept in a large cohort of patients with diverse cancers has yet to be reported. Here we report the results of an analysis of plasma-derived ctDNA from 670 patients with diverse cancers. The tumors represented in the patient cohort were mainly...

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Identifiers

PMID: 28807936
DOI: 10.1158/0008-5472.CAN-17-0885
PMCID: PMC5626633

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EGFR
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