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Detection of mutation profiles and tumor mutation burden of cerebrospinal fluid circulating DNA by a cancer genomic panel sequencing in glioma patients.

Clinica chimica acta; international journal of clinical chemistry - 1 Sept 2022

Guo Wenlong, Jin Lei, Liang Jianhao, Lin Guowang, Zheng Jiantao, Zhou Dong, Zhan Shengquan, Sun Haitao, Jiang Xiaodan

Abstract excerpt

BACKGROUND AND AIMS: Circulating tumor DNA (ctDNA) has been recognized as a reliable source to reflect the molecular and genetic landscape of corresponding tumors in recent years. In this study, we tested the application of a cancer genomic panel sequencing on the cerebrospinal fluid (CSF)-derived ctDNA for the less invasive detection and diagnosis of glioma. MATERIALS AND METHODS: CtDNA was extracted from 26 CSF...

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PMID: 35810802
DOI: 10.1016/j.cca.2022.07.001

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