Article
Molecular profiling of tumors of the brainstem by sequencing of CSF-derived circulating tumor DNA.
Acta neuropathologica - 1 Feb 2019
Pan Changcun, Diplas Bill H, Chen Xin, Wu Yuliang, Xiao Xiong, Jiang Liping, Geng Yibo, Xu Cheng, Sun Yu, Zhang Peng, Wu Wenhao, Wang Yu, Wu Zhen, Zhang Junting, Jiao Yuchen, Yan Hai, Zhang Liwei
Abstract excerpt
Brainstem gliomas are molecularly heterogeneous diseases, many of which are difficult to safely surgically resect and have limited treatment options due to their eloquent location. These constraints pose challenges to biopsy, which limits the use of routine molecular profiling and identification of personalized therapies. Here, we explored the potential of sequencing of circulating tumor DNA (ctDNA) isolated from...
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