Article
Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2015
Wang Yuxuan, Springer Simeon, Zhang Ming, McMahon K Wyatt, Kinde Isaac, Dobbyn Lisa, Ptak Janine, Brem Henry, Chaichana Kaisorn, Gallia Gary L, Gokaslan Ziya L, Groves Mari L, Jallo George I, Lim Michael, Olivi Alessandro, Quinones-Hinojosa Alfredo, Rigamonti Daniele, Riggins Greg J, Sciubba Daniel M, Weingart Jon D, Wolinsky Jean-Paul, Ye Xiaobu, Oba-Shinjo Sueli Mieko, Marie Suely K N, Holdhoff Matthias, Agrawal Nishant, Diaz Luis A, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, Bettegowda Chetan
Abstract excerpt
Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA, here termed CSF-tDNA. We analyzed 35 primary CNS malignancies and found at least one mutation in each tumor using...
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