Clinical Experience of Cerebrospinal Fluid-Based Liquid Biopsy Demonstrates Superiority of Cell-Free DNA over Cell Pellet Genomic DNA for Molecular Profiling.

doi:10.1016/j.jmoldx.2021.03.001

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Article

Clinical Experience of Cerebrospinal Fluid-Based Liquid Biopsy Demonstrates Superiority of Cell-Free DNA over Cell Pellet Genomic DNA for Molecular Profiling.

The Journal of molecular diagnostics : JMD - 1 Jun 2021

Bale Tejus A, Yang Soo-Ryum, Solomon James P, Nafa Khedoudja, Middha Sumit, Casanova Jacklyn, Sadowska Justyna, Skakodub Anna, Ahmad Hamza, Yu Helena A, Riely Greg J, Kris Mark G, Chandarlapaty Sarat, Rosenblum Marc K, Gavrilovic Igor, Karajannis Matthias A, Pentsova Elena, Miller Alexandra, Boire Adrienne, Mellinghoff Ingo, Berger Michael F, Zehir Ahmet, Ladanyi Marc, Benayed Ryma, Arcila Maria E

Abstract excerpt

Cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) offers unique opportunities for genomic profiling of tumors involving the central nervous system but remains uncommonly used in clinical practice. We describe our clinical experience using cfDNA from CSF for routine molecular testing using Memorial Sloan Kettering Integrated Mutation Profiling of Actionable Cancer Targets (targeting 468 cancer-related genes)....

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Identifiers

PMID: 33781965
DOI: 10.1016/j.jmoldx.2021.03.001
PMCID: PMC8207471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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