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Article

Exploring genetic alterations in circulating tumor DNA from cerebrospinal fluid of pediatric medulloblastoma.

Scientific reports - 11 Mar 2021

Sun Yanling, Li Miao, Ren Siqi, Liu Yan, Zhang Jin, Li Shuting, Gao Wenchao, Gong Xiaojun, Liu Jingjing, Wang Yuan, Du Shuxu, Sun Liming, Wu Wanshui, Tian Yongji

Abstract excerpt

Medulloblastoma (MB) is the most common type of brain malignancy in children. Molecular profiling has become an important component to select patients for therapeutic approaches, allowing for personalized therapy. In this study, we successfully identified detectable levels of tumor-derived cell-free DNA (cfDNA) in cerebrospinal fluid (CSF) samples of patients with MB. Furthermore, cfDNA from CSF can interrogate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33707557
DOI: 10.1038/s41598-021-85178-6
PMCID: PMC7952732

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