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Article

Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.

Circulation research - 6 Jul 2012

Risebro Catherine A, Petchey Louisa K, Smart Nicola, Gomes John, Clark James, Vieira Joaquim M, Yanni Joseph, Dobrzynski Halina, Davidson Sean, Zuberi Zia, Tinker Andrew, Shui Bo, Tallini Yvonne I, Kotlikoff Michael I, Miquerol Lucile, Schwartz Robert J, Riley Paul R

Abstract excerpt

RATIONALE: Nkx2.5 is one of the most widely studied cardiac-specific transcription factors, conserved from flies to man, with multiple essential roles in both the developing and adult heart. Specific dominant mutations in NKX2.5 have been identified in adult congenital heart disease patients pres...

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Source

Identifiers

PMID: 22647876
DOI: 10.1161/CIRCRESAHA.111.260695

Genes

HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22647876-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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