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Retroelement Hypomethylation Links Hypoxia Signaling, Immune Phenotypes, and Survival in Clear Cell Renal Cell Carcinoma

2026-05-06

Abstract excerpt

<h4>Background</h4> Retrotransposable elements (RE) comprise approximately 45% of the human genome and are typically repressed by DNA methylation to preserve genomic integrity. In cancer, global DNA hypomethylation can lead to RE derepression, resulting in genomic instability and activation of innate immune pathways through viral mimicry. While individual RE classes have been examined in clear cell renal cell car...

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Literature Corpus work
31ade22f-0b63-5f3a-ae2b-36d55747013d
DOI
10.64898/2026.05.01.722263
Open publication

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Retroelement Hypomethylation Links Hypoxia Signaling, Immune Phenotypes, and Survival in Clear Cell Renal Cell CarcinomaDOI 10.64898/2026.05.01.722263
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