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Article

Epigenetics in renal cell cancer: mechanisms and clinical applications.

Nature reviews. Urology - 1 Jul 2018

Joosten Sophie C, Smits Kim M, Aarts Maureen J, Melotte Veerle, Koch Alexander, Tjan-Heijnen Vivianne C, van Engeland Manon

Abstract excerpt

Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations. By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic reprogramming is an important event in RCC development. Epigenetic alterations comprise several different aberrations, such as changes in histone modifications, DNA methylation, and microRNA levels, and occur in the most important...

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PMID: 29867106
DOI: 10.1038/s41585-018-0023-z

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VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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