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Article

Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma

1 Jun 2024

Abstract excerpt

Renal cell carcinoma with sarcomatoid differentiation (sRCC) is associated with poor survival and a heightened response to immune checkpoint inhibitors (ICIs). Two major barriers to improving outcomes for sRCC are the limited understanding of its gene regulatory programs and the low diagnostic yield of tumor biopsies due to spatial heterogeneity. Herein, we characterized the epigenomic landscape of sRCC by...

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PMID: 38870013
DOI: 10.1016/j.celrep.2024.114350

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