Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency

22 Feb 2019

Abstract excerpt

Abstract There is a growing body of evidence that the molecular properties of leukemia stem cells (LSCs) are associated with clinical outcomes in acute myeloid leukemia (AML), and LSCs have been linked to therapy failure and relapse. Thus, a better understanding of the molecular mechanisms that contribute to the persistence and regenerative potential of LSCs is expected to result in the development of more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Genomics and Chromatin Dynamics
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30796022
DOI: 10.1182/blood-2018-10-881441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latencyPMID 30796022Read ↗

Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional propertiesSemantic proximity Read ↗

Distinct gene regulatory networks govern hematopoietic and leukemia stem cellsSemantic proximity Read ↗

A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genomeSemantic proximity Read ↗

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells.Semantic proximity Read ↗

Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional propertiesSemantic proximity Read ↗

A two-step <i>in vivo</i> CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic targetSemantic proximity Read ↗

Epigenetic mechanisms controlling human leukemia stem cells and therapy resistanceSemantic proximity Read ↗

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to LeukemiaSemantic proximity Read ↗

Epigenetic mechanisms controlling human leukemia stem cells and therapy resistanceSemantic proximity Read ↗

Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growthSemantic proximity Read ↗

EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)Semantic proximity Read ↗

Early epigenetic influence on EGR1, KLF2 and KLF4 transcriptional network associates with alteration of HSCs quiescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.