Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells

22 Feb 2019

Abstract excerpt

Crohn's disease (CD) is a debilitating inflammatory bowel disease (IBD) that arises from chronic inflammation in the gastrointestinal tract. Genome-wide association studies (GWAS) have identified over 200 single nucleotide polymorphisms (SNPs) that are associated with a predisposition for developing IBD. For the majority, the causal variant and target genes affected are unknown. Here, we investigated the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helicobacter pylori-related gastroenterology studies
Share to Immunodeficiency and Autoimmune Disorders
Share to Inflammatory Bowel Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30794691
DOI: 10.1371/journal.pone.0212850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cellsPMID 30794691Read ↗

Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies.Semantic proximity Read ↗

Somatic Evolution in Non-neoplastic IBD-Affected ColonSemantic proximity Read ↗

Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibilitySemantic proximity Read ↗

Somatic evolution in non-neoplastic IBD-affected colonSemantic proximity Read ↗

Somatic inflammatory gene mutations in human ulcerative colitis epithelium.Semantic proximity Read ↗

Cell-type-resolved chromatin accessibility in the human intestine identifies complex regulatory programs and clarifies genetic associations in Crohn’s diseaseSemantic proximity Read ↗

A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.Semantic proximity Read ↗

Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease riskSemantic proximity Read ↗

Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease.Semantic proximity Read ↗

Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci.Semantic proximity Read ↗

Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.Semantic proximity Read ↗

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.