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Article

Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease.

PloS one - 1 Jan 2009

Koslowski Maureen J, Kübler Irmgard, Chamaillard Mathias, Schaeffeler Elke, Reinisch Walter, Wang Guoxing, Beisner Julia, Teml Alexander, Peyrin-Biroulet Laurent, Winter Stefan, Herrlinger Klaus R, Rutgeerts Paul, Vermeire Séverine, Cooney Rachel, Fellermann Klaus, Jewell Derek, Bevins Charles L, Schwab Matthias, Stange Eduard F, Wehkamp Jan

Abstract excerpt

Reduced expression of Paneth cell antimicrobial alpha-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum. TCF-4 (also named TCF7L2), a Wnt signalling pathway transcription factor, orchestrates Paneth cell differentiation, directly regulates the expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19221600
DOI: 10.1371/journal.pone.0004496
PMCID: PMC2637978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19221600-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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