A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.

doi:10.1016/j.celrep.2014.07.020

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Article

A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.

Cell reports - 21 Aug 2014

Lewis Annabelle, Freeman-Mills Luke, de la Calle-Mustienes Elisa, Giráldez-Pérez Rosa María, Davis Hayley, Jaeger Emma, Becker Martin, Hubner Nina C, Nguyen Luan N, Zeron-Medina Jorge, Bond Gareth, Stunnenberg Hendrik G, Carvajal Jaime J, Gomez-Skarmeta Jose Luis, Leedham Simon, Tomlinson Ian

Abstract excerpt

A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 polymorphism, rs16969681, is also associated with CRC susceptibility, conferring ∼20% differential risk in the...

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Share to CDX2 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25131200
DOI: 10.1016/j.celrep.2014.07.020
PMCID: PMC4471812

Genes

GREM1
CDX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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