Article
A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
Nucleic acids research - 7 May 2019
Gopalakrishnan Rajaraman, Marr Sharon K, Kingston Robert E, Winston Fred
Abstract excerpt
The transcription elongation factor Spt6 and the H3K36 methyltransferase Set2 are both required for H3K36 methylation and transcriptional fidelity in Saccharomyces cerevisiae. However, the nature of the requirement for Spt6 has remained elusive. By selecting for suppressors of a transcriptional defect in an spt6 mutant, we have isolated several highly clustered, dominant SET2 mutations (SET2sup mutations) in a...
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