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Article

Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6.

Nucleic acids research - 24 Aug 2026

Elchert Alexandra R, Lux Vanda, Warner James L, Nešporová Tereza, Veverka Václav, Winston Fred

Abstract excerpt

Histone H3 lysine 36 methylation is a conserved histone modification that is critical for maintaining eukaryotic transcriptional fidelity and genomic stability. In Saccharomyces cerevisiae, this modification is catalyzed by Set2, an ortholog of the mammalian H3K36 methyltransferase SETD2. Previous genetic, biochemical, and structural studies showed that Set2 activity is repressed by a Set2 autoinhibitory domain...

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Topics

Saccharomyces cerevisiae Proteins
Histone Chaperones
Saccharomyces cerevisiae
Histones
Transcriptional Elongation Factors
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Methylation

Histone-Lysine N-Methyltransferase

Catalytic Domain

Protein Binding

Transcription, Genetic

Methyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 42683586
DOI: 10.1093/nar/gkag839
PMCID: PMC13535259

Genes

SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6.PMID 42683586Read ↗

A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.Semantic proximity Read ↗

Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.Semantic proximity Read ↗

Balancing acts of SRI and an auto-inhibitory domain specify Set2 function at transcribed chromatin.Semantic proximity Read ↗

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.Semantic proximity Read ↗

Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation.Semantic proximity Read ↗

The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.Semantic proximity Read ↗

Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.Semantic proximity Read ↗

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A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.Semantic proximity Read ↗

Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.Semantic proximity Read ↗

The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation.Semantic proximity Read ↗

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