Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Balancing acts of SRI and an auto-inhibitory domain specify Set2 function at transcribed chromatin.

Nucleic acids research - 26 May 2015

Wang Yi, Niu Yanling, Li Bing

Abstract excerpt

Set2-mediated H3K36 methylation ubiquitously functions in coding regions in all eukaryotes. It has been linked to the regulation of acetylation states, histone exchange, alternative splicing, DNA repair and recombination. Set2 is recruited to transcribed chromatin through its SRI domain's direct association with phosphorylated Pol II. However, regulatory mechanisms for histone modifying enzymes like Set2 that...

Topics

Chromatin
Histone Chaperones
Histone-Lysine N-Methyltransferase
Histones
Mutation
Protein Structure, Tertiary
RNA Polymerase II
Substrate Specificity
Transcription, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 25925577
DOI: 10.1093/nar/gkv393
PMCID: PMC4446442

Genes

SRI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25925577-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Balancing acts of SRI and an auto-inhibitory domain specify Set2 function at transcribed chromatin.PMID 25925577Read ↗

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.Semantic proximity Read ↗

A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.Semantic proximity Read ↗

A nucleosome surface formed by histone H4, H2A, and H3 residues is needed for proper histone H3 Lys36 methylation, histone acetylation, and repression of cryptic transcription.Semantic proximity Read ↗

A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.Semantic proximity Read ↗

Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange.Semantic proximity Read ↗

The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.Semantic proximity Read ↗

Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation.Semantic proximity Read ↗

Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.Semantic proximity Read ↗

The BAH domain of Rsc2 is a histone H3 binding domain.Semantic proximity Read ↗

NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5.Semantic proximity Read ↗

UpSET recruits HDAC complexes and restricts chromatin accessibility and acetylation at promoter regions.Semantic proximity Read ↗

Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.