Article
Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma.
Molecular psychiatry - 1 Dec 2015
Luykx J J, Bakker S C, Visser W F, Verhoeven-Duif N, Buizer-Voskamp J E, den Heijer J M, Boks M P M, Sul J H, Eskin E, Ori A P, Cantor R M, Vorstman J, Strengman E, DeYoung J, Kappen T H, Pariama E, van Dongen E P A, Borgdorff P, Bruins P, de Koning T J, Kahn R S, Ophoff R A
Abstract excerpt
The N-methyl-D-aspartate receptor (NMDAR) coagonists glycine, D-serine and L-proline play crucial roles in NMDAR-dependent neurotransmission and are associated with a range of neuropsychiatric disorders. We conducted the first genome-wide association study of concentrations of these coagonists and their enantiomers in plasma and cerebrospinal fluid (CSF) of human subjects from the general population (N=414)....
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