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Article

Retinoblastoma mutation predicts poor outcomes in advanced non small cell lung cancer

17 Feb 2019

Abstract excerpt

The retinoblastoma gene (RB1) encodes the retinoblastoma (RB) pocket protein that plays an important role in cell cycle progression. Here we determine the frequency and prognostic significance of RB1 mutation in non small cell lung cancer (NSCLC), restricting inclusion to Stage III and IV patients with linked genomic and clinical data. The primary outcome was median overall survival (OS). We identified RB1...

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PMID: 30773851
DOI: 10.1002/cam4.2023

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