Article
RB1-I680T mutation potentiates tumor growth and chemotherapy sensitivity in non-small cell lung cancer via derepressing E2F1 transcription.
Cell communication and signaling : CCS - 31 Jan 2026
Zhu Yilin, Gao Fengyuan, Liu Yu, Wang Jinfu, Liu Fanrong, Wang Biao, Wu Boxuan, Wang Yue, Zhang Yifan, Tian Zhongxian, Mu Ning, Zhang Xianglin, Zhao Xiaogang, Zhao Yunpeng, Li Peichao
Abstract excerpt
BACKGROUND: Retinoblastoma Transcriptional Corepressor 1 (RB1) is a critical tumor suppressor restricting the malignant progression of cancer cells. Emerging evidence indicates that RB1 mutations typically promote tumorigenesis through loss of its tumor-suppressive functions. Yet, the biological significance of mutated RB1, specifically certain rare variants, in non-small cell lung cancer (NSCLC) remains elusive....
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