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Article

Retinoblastoma Expression and Targeting by CDK4/6 Inhibitors in Small Cell Lung Cancer.

Molecular cancer therapeutics - 1 Feb 2023

Wildey Gary, Shay Ashley M, McColl Karen S, Yoon Suzy, Shatat Mohammad A, Perwez Ahmad, Spainhower Kyle B, Kresak Adam M, Lipka MaryBeth, Yang Michael, Behtaj Mohadese, Fu Pingfu, Alahmadi Asrar, Mneimneh Wadad, Abbas Ata, Dowlati Afshin

Abstract excerpt

The canonical model of "small cell lung cancer" (SCLC) depicts tumors arising from dual inactivation of TP53 and RB1. However, many genomic studies have persistently identified tumors with no RB1 mutations. Here, we examined RB1 protein expression and function in SCLC. RB1 expression was examined by IHC analysis of 62 human SCLC tumors. These studies showed that ∼14% of SCLC tumors expressed abundant RB1 protein,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36399634
DOI: 10.1158/1535-7163.MCT-22-0365
PMCID: PMC9898162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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