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Article

Clinically actionable molecular alterations in Rb-retained small cell lung carcinoma variants.

Virchows Archiv : an international journal of pathology - 1 Jul 2026

Zacharias Martin, John Nikolaus, Kashofer Karl, Popper Helmut

Abstract excerpt

Small cell lung carcinoma (SCLC) is classically defined by biallelic inactivation of RB1 and TP53. However, a small subset of tumors retains Rb expression and exhibits distinct molecular features. Here, we report two Rb-retained SCLC cases that expand the biological and therapeutic spectrum of this subgroup. Both tumors occurred in middle-aged women, showed small cell morphology with some variant features, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41811505
DOI: 10.1007/s00428-026-04458-6
PMCID: PMC13368884

Genes

TP53
CCND1
CDKN2A
ERBB4
IKZF2
KRAS
RB1
STK11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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