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Beta cells in type 1 diabetes: mass and function; sleeping or dead?

14 Feb 2019

Abstract excerpt

Histological analysis of donor pancreases coupled with measurement of serum C-peptide in clinical cohorts has challenged the idea that all beta cells are eventually destroyed in type 1 diabetes. These findings have raised a number of questions regarding how the remaining beta cells have escaped immune destruction, whether pools of 'sleeping' or dysfunctional beta cells could be rejuvenated and whether there is...

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PMID: 30767048
DOI: 10.1007/s00125-019-4822-4

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