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Article

Life and death of β cells in Type 1 diabetes: A comprehensive review.

Journal of autoimmunity - 1 Jul 2016

Wilcox Nicholas S, Rui Jinxiu, Hebrok Matthias, Herold Kevan C

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disorder characterized by the destruction of insulin-producing pancreatic β cells. Immune modulators have achieved some success in modifying the course of disease progression in T1D. However, there are parallel declines in C-peptide levels in treated and control groups after initial responses. In this review, we discuss mechanisms of β cell death in T1D that involve necrosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27017348
DOI: 10.1016/j.jaut.2016.02.001
PMCID: PMC4903951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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