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DNA demethylation is associated with malignant progression of lower-grade gliomas

13 Feb 2019

Abstract excerpt

To elucidate the mechanisms of malignant progression of lower-grade glioma, molecular profiling using methylation array, whole-exome sequencing, and RNA sequencing was performed for 122, 36 and 31 gliomas, respectively. This cohort included 24 matched pairs of initial lower-grade gliomas and recurrent tumors, most of which showed malignant progression. Nearly half of IDH-mutant glioblastomas that had progressed...

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PMID: 30760837
DOI: 10.1038/s41598-019-38510-0

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