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Article

The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells.

BMC cancer - 15 Jul 2008

de la Roche Marc, Worm Jesper, Bienz Mariann

Abstract excerpt

BACKGROUND: Most cases of colorectal cancer are initiated by hyperactivation of the Wnt/beta-catenin pathway due to mutations in the APC tumour suppressor, or in beta-catenin itself. A recently discovered component of this pathway is Legless, which is essential for Wnt-induced transcription during Drosophila development. Limited functional information is available for its two mammalian relatives, BCL9 and...

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Topics

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Share to beta Catenin
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Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18627596
DOI: 10.1186/1471-2407-8-199
PMCID: PMC2478683

Genes

BCL9
APC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

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