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Article

MG53, A Novel Regulator of KChIP2 and I to,f , Plays a Critical Role in Electrophysiological Remodeling in Cardiac Hypertrophy

14 Feb 2019

Abstract excerpt

Background: KChIP2 (K + channel interacting protein) is the auxiliary subunit of the fast transient outward K + current ( I to,f ) in the heart, and insufficient KChIP2 expression induces I to,f downregulation and arrhythmogenesis in cardiac hypertrophy. Studies have shown muscle-specific mitsugumin 53 (MG53) has promiscuity of function in the context of normal and diseased heart. This study investigates the...

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Share to Cardiac electrophysiology and arrhythmias
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Identifiers

PMID: 30760025
DOI: 10.1161/circulationaha.118.029413

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