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Article

PCP4 regulates Purkinje cell excitability and cardiac rhythmicity

7 Oct 2014

Abstract excerpt

Cardiac Purkinje cells are important triggers of ventricular arrhythmias associated with heritable and acquired syndromes; however, the mechanisms responsible for this proarrhythmic behavior are incompletely understood. Here, through transcriptional profiling of genetically labeled cardiomyocytes, we identified expression of Purkinje cell protein-4 (Pcp4), a putative regulator of calmodulin and...

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PMID: 25295538
DOI: 10.1172/jci77495

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