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KCNH2 encodes a nuclear-targeted polypeptide that mediates hERG1 channel gating and expression

10 Jan 2023

Abstract excerpt

KCNH2 encodes hERG1, the voltage-gated potassium channel that conducts the rapid delayed rectifier potassium current (I Kr ) in human cardiac tissue. hERG1 is one of the first channels expressed during early cardiac development, and its dysfunction is associated with intrauterine fetal death, sudden infant death syndrome, cardiac arrhythmia, and sudden cardiac death. Here, we identified a hERG1 polypeptide (hERG1...

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PMID: 36626562
DOI: 10.1073/pnas.2214700120

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