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Article

Therapeutic Inhibition of LincRNA-p21 Protects Against Cardiac Hypertrophy

12 Jun 2024

Abstract excerpt

BACKGROUND: Cardiac hypertrophy is an adaptive response to pressure overload aimed at maintaining cardiac function. However, prolonged hypertrophy significantly increases the risk of maladaptive cardiac remodeling and heart failure. Recent studies have implicated long noncoding RNAs in cardiac hypertrophy and cardiomyopathy, but their significance and mechanism(s) of action are not well understood. METHODS: We...

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PMID: 38864216
DOI: 10.1161/circresaha.123.323356

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