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Clonal Hematopoiesis with Oncogenic Potential (CHOP): Separation from CHIP and Roads to AML

12 Feb 2019

Abstract excerpt

The development of leukemia is a step-wise process that is associated with molecular diversification and clonal selection of neoplastic stem cells. Depending on the number and combinations of lesions, one or more sub-clones expand/s after a variable latency period. Initial stages may develop early in life or later in adulthood and include premalignant (indolent) stages and the malignant phase, defined by an acute...

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PMID: 30759825
DOI: 10.3390/ijms20030789

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