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Article

Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage

8 Feb 2019

Abstract excerpt

NSMCE2 is an E3 SUMO ligase and a subunit of the SMC5/6 complex that associates with the replication fork and protects against genomic instability. Here, we study the fate of collapsed replication forks generated by prolonged hydroxyurea treatment in human NSMCE2-deficient cells. Double strand breaks accumulate during rescue by converging forks in normal cells but not in NSMCE2-deficient cells. Un-rescued forks...

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Identifiers

PMID: 30735491
DOI: 10.1371/journal.pgen.1007942

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