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Article

SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells

7 Jul 2017

Abstract excerpt

Abstract Molecular mechanisms preventing self-renewing brain stem cells from oncogenic transformation are poorly defined. We show that the expression levels of SOX5, SOX6, and SOX21 (SOX5/6/21) transcription factors increase in stem cells of the subventricular zone (SVZ) upon oncogenic stress, whereas their expression in human glioma decreases during malignant progression. Elevated levels of SOX5/6/21 promoted...

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PMID: 28687615
DOI: 10.1158/0008-5472.can-17-0704

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