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Article

Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant Transformation

1 Apr 2008

Abstract excerpt

Homeoproteins are transcription factors that act as master regulators of development and are frequently dysregulated in cancers. During embryogenesis, the Six1 homeoprotein is essential for the expansion of precursor cell populations that give rise to muscle and kidney, among other organs. Six1 overexpression is observed in numerous cancers, resulting in increased proliferation, survival, and metastasis. Here, we...

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PMID: 18381426
DOI: 10.1158/0008-5472.can-07-3141

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Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant TransformationPMID 18381426Read ↗

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