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Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition

18 Aug 2009

Abstract excerpt

Six1 is a developmentally regulated homeoprotein with limited expression in most normal adult tissues and frequent misexpression in a variety of malignancies. Here we demonstrate, using a bitransgenic mouse model, that misexpression of human Six1 in adult mouse mammary gland epithelium induces tumors of multiple histological subtypes in a dose-dependent manner. The neoplastic lesions induced by Six1 had an in...

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PMID: 19726883
DOI: 10.1172/jci37691

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Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transitionPMID 19726883Read ↗

Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant TransformationSemantic proximity Read ↗

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Six1 promotes epithelial-mesenchymal transition and malignant conversion in human papillomavirus type 16-immortalized human keratinocytesSemantic proximity Read ↗

Gene Amplification Is a Mechanism of <i>Six1</i> Overexpression in Breast CancerSemantic proximity Read ↗

SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated stateSemantic proximity Read ↗

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DEAR1 Is a Chromosome 1p35 Tumor Suppressor and Master Regulator of TGF-β–Driven Epithelial–Mesenchymal TransitionSemantic proximity Read ↗

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