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The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region

4 Feb 2019

Abstract excerpt

The Human Leucocyte Antigen (HLA) locus and other DNA sequence variants identified in Genome-Wide Association (GWA) studies explain around 50% of the heritability of celiac disease (CD). However, the pathogenesis of CD could be driven by other layers of genomic information independent from sequence variation, such as DNA methylation, and it is possible that allele-specific methylation explains part of the SNP...

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PMID: 30718669
DOI: 10.1038/s41598-018-37746-6

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