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Article

Methylation quantitative trait loci are largely consistent across disease states in Crohn's disease.

G3 (Bethesda, Md.) - 4 Apr 2022

Venkateswaran Suresh, Somineni Hari K, Kilaru Varun, Katrinli Seyma, Prince Jarod, Okou David T, Hyams Jeffrey S, Denson Lee A, Kellermayer Richard, Gibson Greg, Cutler David J, Smith Alicia K, Kugathasan Subra, Conneely Karen N

Abstract excerpt

Recently, we identified 1,189 CpG sites whose DNA methylation level in blood associated with Crohn's disease. Here, we examined associations between DNA methylation and genetic variants to identify methylation quantitative trait loci across disease states in (1) 402 blood samples from 164 newly diagnosed pediatric Crohn's disease patients taken at 2 time points (diagnosis and follow-up), and 74 non-inflammatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35172000
DOI: 10.1093/g3journal/jkac041
PMCID: PMC8982416

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