Article
Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci.
Inflammatory bowel diseases - 1 Oct 2014
Adams Alex T, Kennedy Nicholas A, Hansen Richard, Ventham Nicholas T, OʼLeary Kate R, Drummond Hazel E, Noble Colin L, El-Omar Emad, Russell Richard K, Wilson David C, Nimmo Elaine R, Hold Georgina L, Satsangi Jack
Abstract excerpt
BACKGROUND: As a result of technological and analytical advances, genome-wide characterization of key epigenetic alterations is now feasible in complex diseases. We hypothesized that this may provide important insights into gene-environmental interactions in Crohn's disease (CD) and is especially pertinent to early onset disease. METHODS: The Illumina 450K platform was applied to assess epigenome-wide methylation...
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