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Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners

31 Jan 2019

Abstract excerpt

Eukaryotic DNA methylation prevents genomic instability by regulating the expression of oncogenes and tumor-suppressor genes. The negative effects of dysregulated DNA methylation are highlighted by a strong correlation between mutations in the de novo DNA methyltransferase gene DNA methyltransferase 3 α ( DNMT3A ) and poor prognoses among acute myeloid leukemia (AML) patients. We show here that clinically...

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PMID: 30705090
DOI: 10.1074/jbc.ra118.006795

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