Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF

25 Aug 2022

Abstract excerpt

Initiation and maintenance of transcriptional states are critical for controlling normal tissue homeostasis and differentiation. The cyclin dependent kinases CDK8 and CDK19 (Mediator kinases) are regulatory components of Mediator, a highly conserved complex that orchestrates enhancer-mediated transcriptional output. While Mediator kinases have been implicated in the transcription of genes necessary for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Chromatin Remodeling and Cancer
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36006697
DOI: 10.1172/jci158593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNFPMID 36006697Read ↗

Molecular and in vivo Functions of the CDK8 and CDK19 Kinase ModulesSemantic proximity Read ↗

Opening and changing: mammalian SWI/SNF complexes in organ development and carcinogenesis.Semantic proximity Read ↗

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinasesSemantic proximity Read ↗

Identification of target genes for the CDK subunits of the Mediator complexSemantic proximity Read ↗

A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 ResponseSemantic proximity Read ↗

SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease.Semantic proximity Read ↗

The SWI/SNF ATP-dependent chromatin remodeling complex in cell lineage priming and early developmentSemantic proximity Read ↗

Mediator kinase inhibition drives myometrial stem cell differentiation and the uterine fibroid phenotype through super-enhancer reprogrammingSemantic proximity Read ↗

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndromeSemantic proximity Read ↗

CDK8 and CDK19 kinases have non-redundant oncogenic functions in hepatocellular carcinomaSemantic proximity Read ↗

ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1.Semantic proximity Read ↗

Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.