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Genetic overlap between vascular pathologies and Alzheimer's dementia and potential causal mechanisms

18 Sept 2018

Abstract excerpt

INTRODUCTION: We sought to examine the genetic overlap between vascular pathologies and Alzheimer's disease (AD) dementia, and the potential mediating role of vascular pathologies between AD-related genetic variants and late-life cognition. METHODS: For 2907 stroke-free older individuals, we examined the association of polygenic risk scores for AD dementia (ADPRSs) with vascular pathologies and with cognition....

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PMID: 30240575
DOI: 10.1016/j.jalz.2018.08.002

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