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Article

GDNF and the RET Receptor in Cancer: New Insights and Therapeutic Potential

7 Jan 2019

Abstract excerpt

The Glial cell line-derived neurotrophic Family Ligands (GFL) are soluble neurotrophic factors that are required for development of multiple human tissues, but which are also important contributors to human cancers. GFL signaling occurs through the transmembrane RET receptor tyrosine kinase, a well-characterized oncogene. GFL-independent RET activation, through rearrangement or point mutations occurs in thyroid...

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Identifiers

PMID: 30666215
DOI: 10.3389/fphys.2018.01873

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