Article

Targeting RET in Brain Metastases from Estrogen Receptor Positive Breast Cancer

2025-04-10

Abstract excerpt

Brain metastases (BrM) occur in 10-15% of patients with estrogen receptor (ER)-positive breast cancer, and remain a significant clinical challenge. While current therapeutic paradigms, including surgical resection and systemic therapy, have efficacy in the management of BrM from ER+BC, median overall survival following the diagnosis of BrM is approximately 18 months. The limited efficacy of current therapies, alon...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9ff6ef16-8e4b-5c87-a6ba-aeba57b6a8eb
DOI: 10.1101/2025.04.04.647085

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting RET in Brain Metastases from Estrogen Receptor Positive Breast CancerDOI 10.1101/2025.04.04.647085Read

Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable TargetsSemantic proximity Read

Targeting wild type NTRK decreases brain metastases of lung cancers non-driven by NTRK fusionsSemantic proximity Read

GDNF and the RET Receptor in Cancer: New Insights and Therapeutic PotentialSemantic proximity Read

EGFR as a potent CAR T target in Triple Negative Breast Cancer Brain MetastasesSemantic proximity Read

Overcoming brain-derived therapeutic resistance in HER2+ breast cancer brain metastasisSemantic proximity Read

A comprehensive overview of the relationship between RET gene and tumor occurrenceSemantic proximity Read

Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis.Semantic proximity Read

RET in breast cancer: pathogenic implications and mechanisms of drug resistanceSemantic proximity Read

Ret Receptor Has Distinct Alterations and Functions in Breast Cancer.Semantic proximity Read

Distinct tumor architectures for metastatic colonization of the brainSemantic proximity Read

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer.Semantic proximity Read

Cerebellum metastasis model of HER2-positive breast cancer unveils key role of IL34-induced Arg1+ macrophagesSemantic proximity Read