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Article

Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency

27 Jun 2020

Abstract excerpt

Expansion of human hematopoietic stem cells (HSCs) is a rapidly advancing field showing great promise for clinical applications. Recent evidence has implicated the nervous system and glial family ligands (GFLs) as potential drivers of hematopoietic survival and self-renewal in the bone marrow niche; how to apply this process to HSC maintenance and expansion has yet to be explored. We show a role for the GFL...

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PMID: 32589703
DOI: 10.1182/blood.2020006302

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