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Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients

16 Jan 2019

Abstract excerpt

Abnormal methionine dependence in cancer cells has led to methionine restriction as a potential therapeutic strategy. We hypothesized that genetic variants involved in methionine‐metabolic genes are associated with survival in nonsmall cell lung cancer (NSCLC) patients. Therefore, we investigated associations of 16,378 common single‐nucleotide polymorphisms (SNPs) in 97 methionine‐metabolic pathway genes with...

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PMID: 30650190
DOI: 10.1002/ijc.32128

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