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Article

Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer.

PloS one - 1 Jan 2013

Swartz Michael D, Peterson Christine B, Lupo Philip J, Wu Xifeng, Forman Michele R, Spitz Margaret R, Hernandez Ladia M, Vannucci Marina, Shete Sanjay

Abstract excerpt

PURPOSE: Folate metabolism, with its importance to DNA repair, provides a promising region for genetic investigation of lung cancer risk. This project investigates genes (MTHFR, MTR, MTRR, CBS, SHMT1, TYMS), folate metabolism related nutrients (B vitamins, methionine, choline, and betaine) and their gene-nutrient interactions. METHODS: We analyzed 115 tag single nucleotide polymorphisms (SNPs) and 15 nutrients...

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Source

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Identifiers

PMID: 23372658
DOI: 10.1371/journal.pone.0053475
PMCID: PMC3553105

Genes

MTRR
MTHFR
CBS
MTR
SHMT1
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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